Possible Interaction: 5-Hydroxytryptophan and Tryptophan

“Administration of l-tryptophan 60 min before sacrifice increased 5-hydroxytryptophan , but not 3,4-dihydroxyphenylalanine, in a dose-related manner with the peak effect occurring after 100-300 mg/kg.”

“Tryptophol, tryptamine, dl-tryptazan, and l-5-hydroxytryptophan inhibit oxidation of d-tryptophan by the enzyme-containing extract using 2,6-dichlorophenolindophenol as the electron acceptor.”

“Astudy of the effect of tryptophan metabolites and analogs showed that a blockade of at least 90% was produced by L-tryptophan, D-tryptophan, DL-tryptophan, tryptamine, kynurenine, 5-methyltryptophan, indoleacetic acid, 5-hydroxyindoleacetic acid, serotonin and 5-hydroxytryptophan.”

“Of the other six inhibitors, azaserine is not antagonized by glutamine, hydroxy-l-lysine is antagonized by l-lysine, 5-hydroxytryptophan is antagonized by tryptophan and canavanine by arginine.”