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Discover Supplement-Drug Interactions

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Last Updated: 5 months ago

Possible Interaction: 5-Hydroxytryptophan and Trazodone

Research Papers that Mention the Interaction

In vitro, it has been shown that various types of antidepressive drugs, including TCAs (imipramine; clomipramine); SSRIs (citalopram, fluoxetine, sertraline); lithium; SNRIs (venlafaxine); HCAs trazodone ); RIMAs (moclobemide) and L-5-HTP significantly suppress the ratio of IFNgamma/IL-10 production by peripheral blood immunocytes.
Human psychopharmacology  •  2001  |  View Paper
Rats working for milk reinforcement and exhibiting behavioral depression following administration of 50 mg/kg 5-HTP were pretreated (one hr before 5-HTP) with 1, 2, or 4 mg/kg trazodone with resulting blockade of 5-HTP induced depression of 35, 62 and 70% respectively.
Pharmacology Biochemistry and Behavior  •  1984  |  View Paper
Trazodone antagonizes the head twitch response induced by 5-hydroxytryptophan in rats and mice, or by-5-methoxytryptamine in rats (the ED50 values are 9.3, 5.2, and 10.8 mg/kg respectively).
Polish journal of pharmacology and pharmacy  •  1979  |  View Paper