supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
5-Hydroxytryptophan
drug:
Trazodone
Research Papers that Mention the Interaction
“Chronic administration of trazodone (2 mg/kg trazodone/day) also resulted in a significant blockade of the 5-HTP effect (75%).”
Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression“ Trazodone antagonizes the head twitch response induced by 5-hydroxytryptophan in rats and mice, or by-5-methoxytryptamine in rats (the ED50 values are 9.3, 5.2, and 10.8 mg/kg respectively).”
On the central antiserotonin action of trazodone.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback