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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
5-Hydroxytryptophan
drug:
Tranylcypromine
Research Papers that Mention the Interaction
“Hamsters receiving tranylcypromine plus 5-hydroxytryptophan had a higher plasma glucose concentration (266 ± 19 versus 116 ± 8 mg/dl), lower plasma insulin concentration (19 ± 3 versus 46 ± 8 μU/ml), and lower plasma insulin/glucose ratio (0.06 ± 0.01 versus 0.40 ± 0.06) than control hamsters.”
“When 5-hydroxytryptophan was given to hamsters after tranylcypromine administration , there was a 58-, 73-, 14-, and 10-fold increase in islet, pancreatic, anterior pituitary, and median eminence serotonin, respectively.”
Pancreatic Islets: A Tissue Rich in Serotonin“Intertreatment with doses of 5-hydroxytryptophan as low as 5 mg/kg one hour before meperidine administration markedly increased mortality of mice receiving the tranylcypromine-meperidine combination.”
“In the presence of tranylcypromine , this increased release by 55 mM K+ or 0.10 mMl-5-HTP was partially suppressed if Ca2+ was omitted from the medium.”
Release of serotonin from nerve endings byl-5-hydroxytryptophan,α-methyl-m-tyramine, and elevated potassium ions
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