Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: 5-Hydroxytryptophan and Serotonin

Research Papers that Mention the Interaction

L-5-Hydroxytryptophan acts to inhibit panic, which supports a modulatory role of serotonin in panic disorder.
Psychiatry Research  •  2002  |  View Paper
Increasing 5-HT concentration in milk via inhibiting its reuptake (SSRI), or by increasing the precursor for 5-HT synthesis 5-hydroxytryptophan , accelerated decline in milk synthesis at dry-off.
Domestic animal endocrinology  •  2012  |  View Paper
In general, these supplements appear to act as GABA receptor agonists or to boost GABA levels, although Kava inhibits both norephinephrine uptake and sodium and potassium channels and 5-HTP may act through elevation of serotonin.
Medical science monitor : international medical journal of experimental and clinical research  •  2009  |  View Paper
administration significantly potentiated the mouse head-twitch response induced by 5-hydroxytryptophan (5-HTP, a metabolic precursor to serotonin ), and also, decreased the immobility time in mouse tail suspension test, which was completely prevented by p-chlorophenylalanine (PCPA, an inhibitor of serotonin synthesis) pretreatment.
Pharmacology Biochemistry and Behavior  •  2008  |  View Paper
Increasing 5-HT concentrations by injection of 5-hydroxytryptophan (Tulunay et a1 1976) potentiates morphine-induced antinociception.
The Journal of pharmacy and pharmacology  •  1980  |  View Paper
Several studies have suggested that exogenous administration of the serotonin precursor 5‐hydroxytryptophan (5‐HTP) can result in the ectopic production of serotonin in dopaminergic neurons and a concomitant reduction in dopamine release.
Human psychopharmacology  •  2013  |  View Paper
In this review, we address the possible role of the essential amino acid L-tryptophan or its metabolic derivative 5-hydroxytryptophan in the modulation of serotonin (5-hydroxytryptamine) synthesis and thereby in affecting the pathophysiology of central and peripheral nervous system disorders, including depression and irritable bowel syndrome.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver  •  2003  |  View Paper
In competition studies, 5-HT had high affinity for 5-HT1A and 5-HT2C sites in the brainstem and cortex, but L-5-HTP was > 1,000-fold less active.
Clinical neuropharmacology  •  1996  |  View Paper
Supplementing milk replacer with 5-hydroxytryptophan (serotonin precursor) or fluoxetine (reuptake inhibitor) increases serotonin bioavailability.
Scientific Reports  •  2020  |  View Paper
Treatment with fluoxetine or 5-hydroxytryptophan significantly increased intracellular serotonin concentrations and subsequently increased PTHrP gene expression, which was reduced with transglutaminase inhibition.
PloS one  •  2020  |  View Paper
Show More