Possible Interaction: 5-Hydroxytryptophan and Reserpine

“The inhibitory effect of reserpine was reversed by 5-hydroxytryptophan (5-HTP), but not by L-dihydroxyphenylalanine (L-DOPA).”

“Following reserpine treatment, which removed native yellow fluorescence in the small intestine, exposure to 5-hydroxytryptophan produced yellow fluorescence in axons in both small and large intestine; exposure to tryptophan never restored fluorescence.”

“ Five-hydroxytryptophane , given along with the reserpine , eliminated memory reduction for the passive training; Dopa, given along with the reserpine, did not eliminate memory deficit for the passive training.”

“It increased rectal temperature, antagonised reserpine and apomorphine hypothermia and potentiated the hyperthermic response of haloperidol and 5-hydroxytryptophan (5-HTP) and hypothermic response of betaphenylethylamine (PEA) and L-dopa.”

“The serotonin agonists 5-hydroxytryptophan , fenfluramine and 5-methoxy-N,N-dimethyltryptamine abolish the inducing effect of reserpine.”

“ L-5-Hydroxytryptophan , a 5-hydroxytryptamine precursor, restored the suppressant effect of noxious stimulation blocked by reserpine and p-chlorophenylalanine.”

“However, 5-hydroxytryptophan and DOPA also appeared to have a protective action against reserpine , comparable with that of m-tyrosine.”

“Abstract Increased sensitivity to audiogenic seizures by reserpine was antagonized by 5-hydroxytryptophan (5HTP).”

“A time demonstrated that such protection against reserpine is afforded for at least 24 hr after the administration of α-methyl-5-hydroxytryptophan.”

“Pretreatment of mice with α-methyl-5-hydroxytryptophan prevented the depletion of serotonin stores by reserpine , but did not protect norepinephrine stores.”