Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a month ago

Possible Interaction: 5-Hydroxytryptophan and Mianserin

Research Papers that Mention the Interaction

Chronic treatment with the antidepressant drugs, amitriptyline or mianserin also blocked 5-HTP depression.
Pharmacology Biochemistry and Behavior  •  1984  |  View Paper
Since acute pretreatment with comparable clinical doses of the antidepressive drugs, mianserin , amitriptyline, imipramine, or iprindole, resulted in blockade of the 5-HTP induced depression by 70, 50, 40, and 20% respectively, these drugs can act as antagonists of 5-HT at the postsynaptic serotonin receptor.
Pharmacology Biochemistry and Behavior  •  1981  |  View Paper
However, combined treatment of mianserin or maprotiline with either fluoxetine or 5-hydroxytryptophan significantly decreased beta-receptors even 24h after the last dose.
International journal of clinical pharmacology research  •  1989  |  View Paper
After a single administration only mianserin inhibited the L-5 hydroxytryptophan effect.
Polish journal of pharmacology and pharmacy  •  1989  |  View Paper
The behavioural syndrome induced by 5-hydroxytryptophan and clorgyline was only antagonized on acute treatment by mianserin.
Neuropharmacology  •  1985  |  View Paper
Amitriptyline, doxepin, iprindole, mianserin and trazadone inhibited the prolactin stimulating effects of high doses of 5-HTP and quipazine, suggesting that these drugs have 5-HT receptor blocking properties.
Acta psychiatrica Scandinavica. Supplementum  •  1981  |  View Paper
The potentiation of the extensor reflex of hind limbs of the spinal …, induced 20 hours after the reserpinization by pretreatment with isocarboxazid and 5-HTP was suppressed by Mianserin , even in a low dose of 0.5 mg/kg, and by amitriptyline in a dose of 10 mg/kg.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1980  |  View Paper