supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
5-Hydroxytryptophan
drug:
Meperidine
Research Papers that Mention the Interaction
“Pretreatment with the serotonin reuptake blocker, fluoxetine (10 mg/kg), or a non-hypothermic dose of meperidine (20 mg/kg) significantly potentiated the hypothermia induced by 100 mg/kg of l-5-hydroxytryptophan.”
Meperidine-induced hypothermia in the rat“Intertreatment with doses of 5-hydroxytryptophan as low as 5 mg/kg one hour before meperidine administration markedly increased mortality of mice receiving the tranylcypromine-meperidine combination.”
“This response was significantly augmented if 5-hydroxytryptophan was coadministered with the meperidine.”
“Accordingly, meperidine but not morphine potentiated the hyperpyrexia induced by the 5-HT precursor, 5-hydroxytryptophan.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback