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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
5-Hydroxytryptophan
supplement:
Melatonin
Research Papers that Mention the Interaction
“This suggests that administration of 5-hydroxytryptophan could be used as the basis of a clinical test of pineal function and that melatonin might mediate some clinical effects of 5-hydroxytryptophan.”
5-hydroxytryptophan elevates serum melatonin.“We tested the hypothesis that acute 5-hydroxytryptophan (5-HTP) administration would cause an increase in concentrations of plasma melatonin to levels observed during the spontaneous nocturnal melatonin surge.”
“Intraocular administration of 5-hydroxytryptophan also increases melatonin levels locally, indicating a retinal site of action of the serotonin precursor.”
“When administered systemically at night in darkness, 5-hydroxytryptophan , but not tryptophan, dramatically stimulates melatonin levels in the chick retina in a dose-dependent manner.”
Elevation of melatonin in chicken retina by 5‐hydroxytryptophan: differential light/dark responses
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