Possible Interaction: 5-Hydroxytryptophan and Fenclonine

“administration significantly potentiated the mouse head-twitch response induced by 5-hydroxytryptophan (5-HTP, a metabolic precursor to serotonin), and also, decreased the immobility time in mouse tail suspension test, which was completely prevented by p-chlorophenylalanine (PCPA, an inhibitor of serotonin synthesis) pretreatment.”

“These …) p-CPA … L-5-HTP , two drugs which affect brain serotonin production in opposite ways, both produce large and general decreases of brain protein synthesis; (2) the …-5-HTP does not restore the p-CPA-induced inhibition of brain protein synthesis but induces further decreases of protein synthesis.”

“administration of p-CPA (280 mg/kg, 42 h before the measurement) and L-5-HTP (60 mg/kg, 40 min before the measurement) resulted in an average 82% decrease of plasma methionine incorporation.”

“Administration of 5-hydroxytryptophan reversed the inhibitory action of pCPA on prolactin release.”

“Administration of 5-hydroxytryptophan significantly reversed this stimulatory effect of pCPA on prolactin release but did not modify the release of prolactin induced by ovariectomy.”

“The inhibitory effect of PCPA was reversed by 200 mg/kg of 5-hydroxy-L-tryptophan (5-HTP) but not by the same amount of L-tryptophan (TP).”

“The effects of p-chlorophenylalanine (PCPA) administration on the homo- and heterosexual behavior are suppressed in rats, rabbits and cats by 5-hydroxytryptophan , the direct precursor of serotonin.”

“It also can reverse the rodent models of insomnia induced by p-chlorophenylalanine (PCPA) and caffeine, which could exhibit a synergistic effect with 5-hydroxytryptophan (5-HTP) as well; furthermore, the hypnotic effects of Gomisin N were inhibited by flumazenil (a specific GABAA-BZD receptor antagonist).”

“The effect of p-chlorophenylalanine was counteracted by the intraperitoneal administration of 5-hydroxytryptophan.”

“The exogenous administration of 5-hydroxytryptophan prevented all effects induced by p-chlorophenylalanine in brain tissue.”

“Treatment with 5-hydroxytryptophan (20 mg/kg) increased the concentration of 5-HT in the brain of rats pretreated with either NaCl or PCPA and enhanced the inhibitory effect of CCK-8 on ingestive behavior in the PCPA-, but not NaCl-, treated rats.”

“twice a day with 5-hydroxytryptophan (5-HTP; 50 mg/kg) experienced a partial reversal in the decline in the 1.7 kb VIP mRNA seen 24 h after the first pCPA injection.”

“Conversely, injection of the 5-HT precursor, 5-hydroxytryptophan (5-HTP), reversed this effect of PCPA and attenuated this sensory response of LC neurons in drug-naive animals.”