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Last Updated: 3 years ago

Possible Interaction: 5-Hydroxytryptophan and Dihydroxyphenylalanine

Research Papers that Mention the Interaction

1 The present work was designed to examine the interference of L‐3,4‐dihydroxyphenylalanine (L‐DOPA ) on the cell inward transport of L‐5‐hydroxytryptophan (L‐5‐HTP ) and on its decarboxylation by aromatic L‐amino acid decarboxylase (AAAD) in rat isolated renal tubules.
6 The results presented suggest that L‐5‐HTP and L‐DOPA are using the same transporter (… probably, the organic cation transporter) in order to be taken up into renal tubular cells; L‐DOPA exerts a competitive type of inhibition … the tubular uptake and decarboxylation of L‐5‐HTP.
When the saturation curve … in the presence of L‐DOPA (… L‐5‐HTP in renal tubules was found to be markedly (P < 0.01) reduced (Vmax = 10.5 ± 1.7 nmol … was accompanied by a significant (P < 0.05) increase in Km values (325 [199, 531] μm, n = 4).
British journal of pharmacology  •  1996  |  View Paper
Daily injection of L-dihydroxyphenylalanine (L-DOPA, a dopamine precursor) given 12 hr after 5-hydroxytryptophan (5-HTP, a serotonin precursor) stimulated testicular growth and body weight increase in the spotted munia Lonchura punctulata.
General and comparative endocrinology  •  1992  |  View Paper
Daily injections of dihydroxyphenylalanine (DOPA), a precursor for dopamine synthesis, given 12 hr after daily injections of 5-hydroxytryptophan (5-HTP), a serotonin precursor, induced uterine growth and increased serum thyroxine and luteinizing hormone (LH) concentrations in scotosensitive female hamsters maintained on short daylengths.
Chronobiology international  •  1989  |  View Paper
A combined administration of 5-hydroxytryptophan (30 mg/kg) and alpha-methyl-dihydroxyphenylalanine (100 mg/kg) resulted in the occurrence on the visual cortex of the effects similar to those produced by ketamine.
Farmakologiia i toksikologiia  •  1988  |  View Paper
However, the infusion of dopa , after 5-hydroxytryptophan , decreased its antinatriuretic and antidiuretic effects.
Clinical science  •  1988  |  View Paper
a-Methyldihydroxyphenylalanine inhibited … 5-hydroxytryptophane (5-HTP) but not of histidine2 or of either amine.3 It seemed appropriate to study the effects of other subtances on … uptake of these amines and amino acids in order to see how useful these cells may be for the study of transport.
The Yale journal of biology and medicine  •  1966  |  View Paper
Less dopamine and serotonin are synthesized when L‐DOPA and 5‐HTP are administered as a cocktail.
The Journal of physiology  •  2021  |  View Paper
Daily injections of L-dihydroxyphenylalanine (L-DOPA, dopamine precursor) given 4 h after 5-hydroxytryptophan (5-HTP, serotonin precursor) induced inhibitory responses in recrudescing gonad (in the first week of December) of Indian palm squirrel, a seasonally breeding subtropical animal.
ISRN endocrinology  •  2013  |  View Paper
Using an enzyme preparation from rabbit kidney cortex, the amino acids 3,4-dihydroxyphenylalanine and 5-hydroxytryptophan were found to inhibit each other's enzymatic decarboxylation competitively.
Acta physiologica Scandinavica  •  1960  |  View Paper