Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: 5-Hydroxytryptophan and Dihydroxyphenylalanine

Research Papers that Mention the Interaction

Previous experiments have shown that daily administration of serotonin precursor 5-hydroxytryptophan and dopamine precursor L-dihydroxyphenylalanine given 8h apart during progressive phase of gonadal cycle can lead to a significant decrease in gonadal activity.
General and comparative endocrinology  •  2013  |  View Paper
IC50 values for L-5-HTP (RBE 4, 1026 microM; RBE 4B, 831 microM) obtained in the presence of a nearly saturating (250 microM) concentration of L-DOPA were almost 5-fold those obtained when non-saturating (25 microM) concentrations of L-DOPA were used.
In RBE 4 cells, Vmax values for L-DOPA uptake were identical in the absence and the presence of … L-5-HTP or 150 microM BHC, but Km values (microM) were significantly greater (P<0.05) when L-DOPA uptake was studied … the presence of L-5-HTP or ….
Brain Research  •  1999  |  View Paper
Daily injections of dihydroxyphenylalanine (DOPA), a precursor for dopamine synthesis, given 12 hr after daily injections of 5-hydroxytryptophan (5-HTP), a serotonin precursor, induced uterine growth and increased serum thyroxine and luteinizing hormone (LH) concentrations in scotosensitive female hamsters maintained on short daylengths.
Chronobiology international  •  1989  |  View Paper
A combined administration of 5-hydroxytryptophan (30 mg/kg) and alpha-methyl-dihydroxyphenylalanine (100 mg/kg) resulted in the occurrence on the visual cortex of the effects similar to those produced by ketamine.
Farmakologiia i toksikologiia  •  1988  |  View Paper
Maximum activity in intact islets was about 330 mmol/kg dry islet per h with an apparent Km … a Vmax of about 120 mmol/kg per h with a Km of 0.3 mM. L-5-Hydroxytryptophan , m-tyrosine … decarboxylation of L-dopa in a way … towards those substrates.
Biochimica et biophysica acta  •  1986  |  View Paper