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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
5-Hydroxytryptophan
drug:
Corticosterone
Research Papers that Mention the Interaction
“Thus, although corticosterone itself does not influence melatonin rhythms of snakes, corticosterone can inhibit the synthesis of melatonin from 5-hydroxytryptophan.”
Temporally distinct effects of stress and corticosterone on diel melatonin rhythms of red-sided garter snakes (Thamnophis sirtalis).“Mice which had been given corticosterone for 10 days displayed the serotonin syndrome when injected with 5-hydroxytryptophan (5-HTP, 100 mg/kg, s.c.),”
“The ACTH and corticosterone levels augment by L-5HTP and decrease by pCPA in all age groups, but this corresponding increase or decrease was less marked in the older rats.”
“Indirect-acting serotonin agonists - fluoxetine, L-5-hydroxytryptophan and p-chloroamphetamine - also increased serum corticosterone concentrations.”
“Administration of other beta-carbolines or the 5-HT precursor 5-hydroxytryptophan also resulted in plasma corticosterone elevations.”
“Since Lilly 110140 is a specific inhibitor of serotonin uptake, these results support the hypothesis that L-5HTP elevates corticosterone by enhancing neurotransmission through a serotoninergic pathway influencing ACTH release.”
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