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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
5-Hydroxytryptophan
supplement:
Cocaine
Research Papers that Mention the Interaction
“Using selective monoamine uptake blockers and appropriate selective monoamine receptor antagonists, we have previously shown that cocaine enhances the frequency of 5-HT2A receptor-mediated 5-hydroxytryptophan (5-HTP)-induced head-twitch response (HTR) in mice via inhibition of serotonin uptake.”
Differential potentiation of L-tryptophan-induced head-twitch response in mice by cocaine and sertraline.“Pretreatment with fluoxetine or cocaine potentiated the head-shake response to the 5-HT precursor, 5-hydroxytryptophan (5-HTP; 75 mg/kg), a behavior mediated by the activation of 5-HT2 receptors.”
“When cocaine and 5-HTP were administered simultaneously the changes in serotonin and SPLI were attenuated, suggesting that each substance antagonized the effect of the other.”
“These newly discovered “enterochromaffin-like” cells, which normally store neither catecholamines nor 5-hydroxytryptamine, can take up L-DOPA (or 5-hydroxytruptophan ) by an active mechanism that can be blocked with cocaine.”
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