supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
supplement:
5-Hydroxytryptophan
drug:
Buspirone
Research Papers that Mention the Interaction
“The suppressant effect of 5-hydroxytryptophan was antagonized or reversed by buspirone , a partial agonist at postsynaptic 5-HT1A receptors, and also by the "silent" 5-HT1A receptor antagonist WAY 100635, but not by the full agonist 8-OH-DPAT.”
Characterization of serotonergic mechanisms involved in the behavioural inhibition induced by 5-hydroxytryptophan in a modified light-dark test in mice.“The decrease was due apparently to a reduced turnover of serotonin; the accumulation of 5-hydroxytryptophan after decarboxylase inhibition was also suppressed by buspirone , not only in hypothalamus but also in brain stem, hippocampus and striatum.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback