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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
5-Hydroxytryptophan
drug:
Buspirone
Research Papers that Mention the Interaction
“The suppressant effect of 5-hydroxytryptophan was antagonized or reversed by buspirone , a partial agonist at postsynaptic 5-HT1A receptors, and also by the "silent" 5-HT1A receptor antagonist WAY 100635, but not by the full agonist 8-OH-DPAT.”
Characterization of serotonergic mechanisms involved in the behavioural inhibition induced by 5-hydroxytryptophan in a modified light-dark test in mice.“The decrease was due apparently to a reduced turnover of serotonin; the accumulation of 5-hydroxytryptophan after decarboxylase inhibition was also suppressed by buspirone , not only in hypothalamus but also in brain stem, hippocampus and striatum.”
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