Possible Interaction: 5-Hydroxytryptophan and Benserazide

“The plasma concentrations of 5-hydroxytryptophan were increased about ten fold by pretreatment with the decarboxylase inhibitors, carbidopa and benserazide.”

“ dl-5-HTP (25–100 mg/kg) in combination with an inhibitor of peripheral 5-HTP decarboxylase ( benserazide , 25 mg/kg) produced, like chlorimipramine and thioridazine, a prolongation of ejaculation latency and an increase in the number of mounts preceding ejaculation.”

“The hypothermic effect of 5-HTP was potentiated by benserazide (1.25-2.5 mg/kg).”

“The potentiating effect of 4 mM L-5-HTP on glucose-induced insulin release was inhibited by the decarboxylase inhibitors benserazide (100 microM), alpha-monofluoromethyldopa (10 or 100 microM), carbidopa (50 or 500 microM), and NSD 1015 (5 or 50 microM).”

“The restoration by 5-hydroxytryptophan was prevented by the inhibitor of L-aminoacid decarboxylase, benserazide.”

“Pretreatment (1 or 4 hr) with benserazide (25–400 mg/kg) produced a dose- and time-dependent blockade of the hypothermic effects of 25 mg/kg and 200 mg/kg of l-5-HTP.”

“The response decrement produced by 25 mg/kg l-5-HTP was completely antagonized by pretreatment with either 50 mg/kg or 400 mg/kg of the decarboxylase inhibitor, benserazide (Ro4-4602).”

“The effectiveness of 5-hydroxytryptophan is abolished in cats pretreated with both para-chlorophenylalanine and seryl-trihydroxybenzyl-hydrazine.”