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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
5-Hydroxytryptophan
drug:
Baclofen
Research Papers that Mention the Interaction
“ Baclofen antagonized the myoclonic effect of 5-hydroxytryptophan in rats with serotonin lesions.”
GABA and Epilepsy: Their Complex Relationship and the Evolution of Our Understanding“administration of racemic baclofen (10-40 mg/kg), a gamma aminobutyric acidB (GABAB) Receptor agonist, increased striatal and hippocampal 5-hydroxytryptophan (5-HTP) accumulation after inhibition of L-aromatic amino acid decarboxylase.”
Modulation of striatal serotonin metabolism by baclofen, a gamma-aminobutyric acidB receptor agonist.“Inhibition by baclofen of wet dog shakes was reversed by 5-hydroxytryptophan (5-HTP) suggesting that the inhibiting effects of GABA mimetics are mediated by serotoninergic neurons.”
“The harmaline+5-hydroxytryptophan syndrome was blocked by drugs acting at benzodiazepine receptors (CL 218,872 greater than ethyl-beta-carboline-3-carboxylate, clonazepam, diazepam, Ro 15-1788, pentobarbital), and baclofen.”
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