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“Acute pretreatment with clinically equivalent doses of antidepressive drugs has been observed to block D, L-5-hydroxytryptophan (5-HTP) induced behavioral depression in rats working on a food-reinforced operant schedule.”
Pharmacology Biochemistry and Behavior • 1984 | View Paper
“In manic-depressive patients, the uptake of L-5-HTP is increased during the depressive phase , while the uptake of L-DOPA, is increased during the manic phase.”