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Last Updated: 4 months ago

Possible Interaction: 5-Hydroxytryptophan and Amitriptyline

Research Papers that Mention the Interaction

Chronic treatment with the antidepressant drugs, amitriptyline or mianserin also blocked 5-HTP depression.
Pharmacology Biochemistry and Behavior  •  1984  |  View Paper
Since acute pretreatment with comparable clinical doses of the antidepressive drugs, mianserin, amitriptyline , imipramine, or iprindole, resulted in blockade of the 5-HTP induced depression by 70, 50, 40, and 20% respectively, these drugs can act as antagonists of 5-HT at the postsynaptic serotonin receptor.
Pharmacology Biochemistry and Behavior  •  1981  |  View Paper
Amitriptyline , one of the commonly prescribed antidepressive drugs, reduced the behavioral depression following 5-HTP by approximately 50%.
Pharmacology Biochemistry and Behavior  •  1980  |  View Paper
Both amitriptyline and isocarboxazid caused a significant increase of brain 5-HT concentration in 5-HTP treated mice.
Psychopharmacology  •  1976  |  View Paper
Amitriptyline (10 mg/kg PO) slightly decreased the number of l-5-hydroxytryptophan (5-HTP)-induced head twitches.
Psychopharmacology  •  1986  |  View Paper
AMINO antagonizes the head twitch reaction induced by 5-hydroxytryptophan in mice and tryptamine convulsions in rats.
Pharmacopsychiatria  •  1982  |  View Paper
Amitriptyline , doxepin, iprindole, mianserin and trazadone inhibited the prolactin stimulating effects of high doses of 5-HTP and quipazine, suggesting that these drugs have 5-HT receptor blocking properties.
Acta psychiatrica Scandinavica. Supplementum  •  1981  |  View Paper
Administration of amitriptyline , a selective serotonin reuptake inhibitor, reversed the depression in the MSR amplitude produced by 5-HTP and produced an increase in the MSR above the original pre-5-HTP control level.
Neuropharmacology  •  1981  |  View Paper
The potentiation of the extensor reflex of hind limbs of the spinal …, induced 20 hours after the reserpinization by pretreatment with isocarboxazid and 5-HTP was suppressed by Mianserin, even in a low dose of 0.5 mg/kg, and by amitriptyline in a dose of 10 mg/kg.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1980  |  View Paper
It was observed that AMI at low doses antagonized the head twitch response to L-5-hydroxytryptophan or 5-methoxytryptamine, as well as tryptamine-induced convulsions.
Pharmakopsychiatrie, Neuro-Psychopharmakologie  •  1979  |  View Paper
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