Possible Interaction: 4-Aminopyridine and Tubocurarine

“4-Aminopyridine 4-AP ) at more than 3 X 10(-4) M induced a chloride current (ICl) which could be blocked by D-tubocurarine.”

“amplitude by tubocurarine was reversed by 4-aminopyridine while the decrease of tau was not.”

“A 75–85 per cent ganglionic blockade produced by hexamethonium, 3 mg/kg, or by d-tubocurarine , 1.0 to 1.2 mg/kg, was completely reversed by 4-aminopyridine , 1 mg/kg.”

“After injection of 4-aminopyridine , the times required for the contractions of the nictitating membrane to increase from 25 to 75 per cent of control with preganglionic stimulation were 6 ± 3 (mean ± SEM) and 7 ± 2 min for hexamethonium and d-tubocurarine , respectively.”

“It is concluded that 4-aminopyridine rapidly and completely reverses the sympathetic ganglion blockade produced by hexamethonium or d-tubocurarine , and is partially effective in the reversal of the autonomic effects of polymyxin B.”

“The block caused by d-Tc and lidocaine was partially antagonized by neostigmine or 4-aminopyridine.”

“In junctions blocked by d-tubocurarine, 4-AP first increased and then decreased the amplitude of e.p.p.s.”

“Micromolar concentrations of 4-aminopyridine (4-AP) were able to increase the amplitude of the end-plate current in frog neuromuscular junction blocked either by d-tubocurarine or by low Ca++ high Mg++ medium.”