supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 5 years ago
drug:
4-Aminopyridine
supplement:
Resveratrol
Research Papers that Mention the Interaction
“In the presence of the endothelium, indomethacin (a nonselective cyclooxygenase inhibitor), methylene blue (cyclic guanosine monophosphate … (L-NAME, nitric oxide synthase inhibitor), tetraethylammonium (TEA, nonselective calcium activator potassium channel blocker), 4-aminopyridine (4-AP, voltage-dependent K+ channel blocker), barium … significant reduction in the vasorelaxation effect induced by resveratrol.”
Vasorelaxant effect of 3,5,4′-trihydroxy-trans-stilbene (resveratrol) and its underlying mechanism“Result showed that the release of glutamate evoked by 4-aminopyridine (4-AP) was inhibited by resveratrol in a concentration-dependent manner.”
“In artery rings without endothelium, the vasorelaxation induced by Res was attenuated by 4-aminopyridine (100 µM) and glibenclamide (10 µM).”
Endothelium-dependent and-independent relaxation induced by resveratrol in rat superior mesenteric arteries.“Relaxation induced by resveratrol was prevented by the addition of verapamil, Nω-nitro-L-arginine-methyl ester, and 4-aminopyridine.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback