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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
4-Aminopyridine
supplement:
Quinidine
Research Papers that Mention the Interaction
“In the presence of 0.2–1 mM 4-AP, quinidine slowed charge return and caused partial charge immobilization, corresponding to an increase in the K d of ∼20-fold.”
“This demonstrated access of quinidine to 4-AP-blocked channels, a lack of competition between the two drugs, and implied allosteric modulation of the quinidine binding site by 4-AP resident within the channel.”
On the Mechanism by which 4-Aminopyridine Occludes Quinidine Block of the Cardiac K+ Channel, hKv1.5“Whole-cell current recordings revealed a transient outward K+-selective current that was blockable in a dose-dependent manner by 4-aminopyridine 4-AP ) and quinidine.”
Transient outwardly rectifying potassium channel in the rabbit corneal endothelium“ 4-AP increased the maximal depolarization velocity and decreased the effects of quinidine.”
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