Possible Interaction: 4-Aminopyridine and Potassium

“ 4-AP application (0,2 mM) reduced potassium current amplitude of the retinal neurons.”

“The potassium current was inhibited by 4-AP and by Heteropodatoxin, a specific blocker of Kv4.2 and Kv4.3 channels, but not by Stromatoxin, a blocker of Kv4.2 channels.”

“ Transient potassium currents were reduced by 4-aminopyridine and sodium currents were blocked by tetrodotoxin.”

“Tetraethylammonium-sensitive … the transient potassium … 4-aminopyridine increased only about 2.5-fold from 174 pA/pF to 442 pA/pF. The Ba2(+)-sensitive current increased simultaneously from … cell differentiation accounted for the changes in decay kinetics of Ca2(+)-independent voltage-activated potassium current observed in later postnatal stages.”

“Application of 4-aminopyridine , an antagonist of the rapidly inactivating potassium current IA, reduced the threshold for dendritic spikes in slices from naive animals to levels found in slices from trained animals.”

“The potassium current was blocked by tetraethylammonium, 4-aminopyridine , barium and cobalt.”

“A transient potassium current was activated by depolarizations positive to -20 mV. This current was blocked by 4-aminopyridine (2 mM) and inactivated with a time constant of approximately 500 ms.”

“The potassium current was blocked by 4-AP.”

“ 4-aminopyridine is a pharmacological blocker that reduces potassium conductance through potassium channels in nerve and muscle.”

“Tetraethylammonium and 4-aminopyridine effectively blocked potassium outward currents but failed to distinguish this calcium-dependent potassium channel from the other two potassium channels in this preparation.”