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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
4-Aminopyridine
supplement:
Glycine
Research Papers that Mention the Interaction
“ 4-Aminopyridine , which blocks K+-conductance of excitable membranes, reversibly abolished both the glial depolarization and the [K+]0 increase produced by GABA and glycine.”
Evidence that the depolarization of glial cells by inhibitory amino acids is caused by an efflux of K+ from neurones“Likewise, infusion of 4-AP into the hippocampus resulted in a major increase in glutamate, as well as slight increases in taurine and glycine.”
“Perfusion with 20-75 mM 4-AP for 12.5 min resulted in a massive increase in extracellular glutamate (up to 20-fold), smaller increases in aspartate and taurine (up to 10-fold) and slight increments in glutamine, alanine, glycine and GABA.”
“ 4-AP which blocks K+-conductance of excitable cells reversibly abolished both the glial depolarization and the increase of extracellular K+-concentration caused by GABA and glycine.”
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