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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
4-Aminopyridine
supplement:
Glucose
Research Papers that Mention the Interaction
“10 mM 4-AP also reduced the insulin release from islets incubated over 90 min in the presence of both 6 and 16.7 mM glucose and from perifused islet in the presence of 16.7 mM glucose.”
“10 mM 4-AP significantly reduced the glucose oxidation of islets incubated for 120 min in the presence of 16.7 mM glucose.”
“ 4-AP (10 mM) only transiently increased the insulin release and the 45Ca2+ fractional efflux in the presence of 6 mM glucose.”
Cation transport by pancreatic beta-cells: effect of 4-aminopyridine on 86Rb+ and 45Ca2+ fluxes.“In intact normal mice, the insulin secretion induced by a half-maximal dose of glucose was partially inhibited by 4-AP , 0.26 micro mol/kg.”
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