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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
4-Aminopyridine
supplement:
Capsaicin
Research Papers that Mention the Interaction
“In contrast, capsaicin enhanced 4-AP induced epileptiform activity in vitro (1-100μM) and triggered bursting activity in vivo (100μM dialysis perfusion), which was abolished by the TRPV1 antagonist CZP.”
TRPV1 antagonist capsazepine suppresses 4-AP-induced epileptiform activity in vitro and electrographic seizures in vivo
“ Capsaicin (200 microM) reversibly blocked both components of the transmitter-activated potassium conductance similarly to other potassium channel blockers such as Ba2+, quinine or 4-aminopyridine.”
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