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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
4-Aminopyridine
supplement:
Caffeine
Research Papers that Mention the Interaction
“ 4-Aminopyridine (0.5 mM) markedly increased the level of the adult AP plateau without suppressing the initial notch, which disappeared after further addition of caffeine (10 mM).”
Age-related changes of action potential plateau shape in isolated human atrial fibers.“Although tetraethylammonium (TEA) and charybdotoxin only slightly potentiated twitch contraction, 4-AP , but not TEA, also augmented a contractile response to caffeine.”
“These results suggest that, although the specific concentration range is rather small, 4-AP elicits an inhibition of SR Ca(2+)-pumping activity, leading to the marked potentiation of muscle contractile responses to electrical stimuli and caffeine.”
Inhibitory action of 4-aminopyridine on Ca(2+)-ATPase of the mammalian sarcoplasmic reticulum.“ Caffeine's … 4-aminopyridine (tension induced by NE: 1.52 ± 0.41 g, tension after adding cumulative concentrations of caffeine: 1.50 ± 0.37 g,P> 0.… by NE: 0.68 ± 0.34 g, tension after adding cumulative concentrations of caffeine: 0.67 ± 0.33 g,P> 0.05).”
Role of Various Potassium Channels in Caffeine-induced Aortic Relaxation in Rats
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