supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
4-Aminopyridine
supplement:
Berberine
Research Papers that Mention the Interaction
“ Berberine inhibited the release of glutamate evoked by the K+ channel blocker 4-aminopyridine ( 4-AP ), and this phenomenon was prevented by the chelating extracellular Ca2+ ions and the vesicular transporter inhibitor bafilomycin A1, but was insensitive to the glutamate transporter inhibitor DL-threo-beta-benzyl-oxyaspartate.”
Berberine Inhibits the Release of Glutamate in Nerve Terminals from Rat Cerebral Cortex“Conclusion: The results of present study show that berberine attenuates 4-AP induced seizures by decreasing hippocampal aspartate and glutamate release in rats.”
“Results: Our findings suggest that berberine significantly delayed the seizure onset following 4-AP injection.”
Berberine attenuates convulsing behavior and extracellular glutamate and aspartate changes in 4-aminopyridine treated rats
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback