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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
4-Aminopyridine
supplement:
Arachidonic Acid
Research Papers that Mention the Interaction
“ Arachidonic acid-induced relaxation was significantly inhibited by glibenclamide (1 microM, ATP-dependent K(+) channel (K(ATP)) blocker), apamin and charybdotoxin (… small (SK(Ca)) and 0.1 microM big (BK(Ca)) conductance Ca(2+)-sensitive K(+) channel blocker, respectively), and 4-aminopyridine (1 mM, voltage-dependent … (K(V)) blocker).”
Arachidonic acid relaxes human pulmonary arteries through K+ channels and nitric oxide pathways.“In fact, arachidonic acid reduced dendritic excitability when applied after 4-AP.”
Arachidonic Acid Reciprocally Alters the Availability of Transient and Sustained Dendritic K+ Channels in Hippocampal CA1 Pyramidal Neurons“Inhibition of voltagegated K+ channels with 4-aminopyridine mimicked the effects of AA.”
“Inhibition of AA metabolites of the lipoxygenase pathway by nordihydroguaiaretic acid, 5,8,11,14-eicosatetranoic acid , and caffeic acid results in a concentration-dependent inhibition of VIP release evoked by 4-AP.”
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