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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: 4-Aminopyridine and Arachidonic Acid

Research Papers that Mention the Interaction

Arachidonic acid-induced relaxation was significantly inhibited by glibenclamide (1 microM, ATP-dependent K(+) channel (K(ATP)) blocker), apamin and charybdotoxin (… small (SK(Ca)) and 0.1 microM big (BK(Ca)) conductance Ca(2+)-sensitive K(+) channel blocker, respectively), and 4-aminopyridine (1 mM, voltage-dependent … (K(V)) blocker).
European journal of pharmacology  •  2004  |  View Paper
In fact, arachidonic acid reduced dendritic excitability when applied after 4-AP.
The Journal of Neuroscience  •  1999  |  View Paper
Inhibition of voltagegated K+ channels with 4-aminopyridine mimicked the effects of AA.
The American journal of physiology  •  1997  |  View Paper
Inhibition of AA metabolites of the lipoxygenase pathway by nordihydroguaiaretic acid, 5,8,11,14-eicosatetranoic acid , and caffeic acid results in a concentration-dependent inhibition of VIP release evoked by 4-AP.
The Journal of neuroscience : the official journal of the Society for Neuroscience  •  1989  |  View Paper