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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
3-Nitrotyrosine
supplement:
Vitamin C
Research Papers that Mention the Interaction
“Supplementation with ascorbic acid (1 g twice a day for 4-12 months) led to a significant reduction in nitrotyrosine staining.”
Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants.“Western blot analysis of nitrotyrosine failed to show inhibition of free radical production by AA, however, our results show that AA inhibits both necrotic and apoptotic cell death and that AA is neuroprotective after HI in immature rat brain.”
Ascorbic acid protects the newborn rat brain from hypoxic-ischemia“ Ascorbic acid prevented the increased plasma lipid peroxidation and nitrotyrosine formation within the carotid body, and the enhanced carotid chemosensory and ventilatory responses to hypoxia, as well as heart rate variability alterations and hypertension.”
“This oxidation of deoxyguanosine, as well as the peroxynitrite-mediated nitration of tyrosine to 3-nitrotyrosine , was significantly inhibited by ascorbic acid , glutathione and (−)-epigallocatechin gallate, a polyphenolic antioxidant present in tea.”
“ Vitamin C supplementation was also associated with a statistically significant reduction in nitrotyrosine level and incremental increase in reduced glutathione.”
Efficacy of Antioxidant Treatment in Reducing Resistin Serum Levels: A Randomized Study“Coadministration of vitamin C caused complete elimination of tolerance and a decrease in urinary nitrotyrosine to 130 ± 28 μg/day.”
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