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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
3-Nitrotyrosine
drug:
Telmisartan
Research Papers that Mention the Interaction
“Interestingly, the telmisartan treatment not only reduced the circulating levels of two oxidative stress markers, 8-hydroxy-2′-deoxyguanosine (8-OHdG) and nitrotyrosine ( NT ), but also enhanced serum SOD activity.”
Reduction of circulating superoxide dismutase activity in type 2 diabetic patients with microalbuminuria and its modulation by telmisartan therapy“Long-term (8 weeks) administration of telmisartan , an angiotensin II type 1-receptor antagonist, prevented the impaired vasorelaxation, decreased sGC expression and increased nitrotyrosine content in mesenteric arteries.”
Chronic production of peroxynitrite in the vascular wall impairs vasorelaxation function in SHR/NDmcr-cp rats, an animal model of metabolic syndrome.“ Telmisartan decreased the serum levels of lipid peroxide and 8-hydroxy-2′-deoxyguanosine, oxidative stress markers, and also the aortic levels of the protein expression of gp91phox, a component of NADPH oxidase, and 3-nitrotyrosine , a biomarker of peroxynitrite.”
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