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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
3-Nitrotyrosine
drug:
Simvastatin
Research Papers that Mention the Interaction
“ Simvastatin , independent of its association with alpha-tocopherol, reduced plasma concentrations of LDL-, nitrotyrosine , total cholesterol, and LDL cholesterol and the LDL cholesterol/HDL cholesterol ratio.”
Antioxidant effect of simvastatin is not enhanced by its association with alpha-tocopherol in hypercholesterolemic patients.“ SIM increased endothelial NO synthase protein levels and blocked diabetes-induced increases in DCF and nitrotyrosine labeling in diabetic coronary vessels.”
Simvastatin Improves Diabetes-Induced Coronary Endothelial Dysfunction“ Simvastatin also inhibited the formation of 3-nitrotyrosine in striatal proteins in MPTP-treated mice.”
“ Simvastatin treatment inhibited the increases in myocardial nitrotyrosine content and in p67-phox and p22-phox expression, and significantly reduced LVH.”
“ Simvastatin also decreased tubular immunoreactivity of inducible-NOS, nitrotyrosine , nuclear-factor-kappaB, and tubuloglomerular trichrome staining.”
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