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Discover Supplement-Drug Interactions

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Last Updated: 5 years ago

Possible Interaction: 3-Nitrotyrosine and Febuxostat

supplement:

3-Nitrotyrosine

drug:

Febuxostat

Research Papers that Mention the Interaction

“ Febuxostat significantly suppressed XO activity, and thereby reduced oxidative stress, assessed by nitrotyrosine , thiobarbituric acid-reactive substances (TBARS) and urine 8-isoprostane.”
Febuxostat suppressed renal ischemia-reperfusion injury via reduced oxidative stress.
Biochemical and biophysical research communications  •  2012  |  View Paper
“ResultsTreatment with febuxostat diminished XO activity in obstructed kidneys, and suppressed nitrotyrosine , a marker of oxidative stress.”
Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy
Clinical and Experimental Nephrology  •  2012  |  View Paper
“ Febuxostat blunted the TAC-induced increases in nitrotyrosine (indicating reduced myocardial oxidative stress), p-Erk(Thr202/Tyr204), and p-mTOR(Ser2488), with no effect on total Erk or total mTOR.”
Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice.
Journal of cardiac failure  •  2008  |  View Paper