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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
3-Nitrotyrosine
drug:
Edaravone
Research Papers that Mention the Interaction
“Also, plasma 8-isoprostane concentrations and aortic nitrotyrosine , 4-HNE and VCAM-1 contents were decreased by edaravone treatment.”
Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis.“ Edaravone blocked the increase in 3-nitrotyrosine immunoreactivity and the activation of astrocytes, but it did not affect the activation of microglia.”
“ Edaravone markedly suppressed the accumulation of HNE-modified protein and 8-OHdG at the penumbra area during the early period after reperfusion (P<0.05) and reduced microglial activation, iNOS expression, and nitrotyrosine formation at the late period.”
“ EDR also reduced the levels of 4-hydroxy-2-nonenal and 3-nitrotyrosine adducts.”
Preclinical validation of a novel oral Edaravone formulation for treatment of frontotemporal dementia.
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