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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
3-Nitrotyrosine
Research Papers that Mention the Interaction
“The apoptosis markers cleaved caspase-3 and fractin as well as oxidative stress markers 3-nitrotyrosine and malondialdehyde were dose-dependently increased by DOX treatment.”
The anti-cancer drug doxorubicin induces substantial epigenetic changes in cultured cardiomyocytes.“Notably, DOXO administration significantly increased nitrotyrosine expression in mouse heart.”
“Various NO donors when coadministered with DOX but not alone dramatically enhanced DOX-induced cell death with concomitant increased NT formation.”
“Furthermore, it reduced DXR induced lipid peroxidation, PCs content, NT concentration and iNOS induction in myocardial tissue (P<0.05).”
“Statistically significant (P <.05) increases in the immunoprevalence of myocardial inducible nitric oxide synthase (33 +/- 18 versus 9 +/- 2%, via quantitative image analysis) and 3-nitrotyrosine formation (56 +/- 24 versus 0.3 +/- 0.4%) were also observed after doxorubicin.”
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