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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Possible Interaction: 3-Hydroxy-5-(2-(4-Hydroxyphenyl)Ethenyl)Phenyl-Beta-D-Glucoside and Sphingosine 1-Phosphate
Research Papers that Mention the Interaction
“In comparison with db/db model group, PD treatment suppressed SphK1 levels (mRNA, protein expression, and activity) and S1P production, reversed the upregulation of FN, ICAM-1, c-Jun, and c-Fos in the kidney tissues of diabetic mice, and finally ameliorated renal injury in db/db mice.”
“Simultaneously, PD dose-dependently inhibited SphK1 levels at the protein expression and kinase activity and attenuated S1P production under AGEs treatment conditions.”
Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway
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