Possible Interaction: 3,4-Methylenedioxyamphetamine and Melatonin

“ Melatonin decreased MDA level in the lung and heart tissues.”

“… melatonin group, …, and MDA levels decreased significantly (p<0.05) from 3.52±0.72 pg/ml, 27.12±6.32 pg/ml, 2.54±0.49 ….29 nmol/l to 1.73±0.07, 16.34±6.32, 1.67±0.27, and 2.79±0.29, respectively.”

“In addition, melatonin was detected to cause a significant decrease of MDA , MMP-9 and TnT levels which were found to be significantly higher on rats with Ep (p<0.05) while having no significant effect on antioxidant levels (GSH, SOD, and CAT) (p >0.05).”

“Results MT pretreatment can significantly reduce neurological deficit score and neuronal apoptosis, inhibit CIRI autophagy, inflammation and oxidative stress in vivo and in vitro, reduce LC3II/LC3I, TNF-α, IL-6, MDA and increase P62, IL-10, GSHPx, SOD.”

“Secondly, MT attenuated the AlCl3-induced oxidative stress in rat spleen by decreasing the levels of ROS and MDA , while increasing the activities of SOD and CAT.”

“On the contrary, levels of MDA , ROS and inflammatory factors (TNF-α, IL-1β, IL-6 and KC-GRO) were markedly decreased after melatonin treatment.”

“The apoptosis rate, ROS level and malonaldehyde MDA ) declined with melatonin.”

“However, zinc and melatonin supplementation inhibited MDA and increased GSH levels in I/R groups.”

“Conversely, melatonin administration in each reproductive phase led to a significant reduction of MDA and elevations of SOD, CAT, GPx, GST, GSH, as well as melatonin levels in the ovary.”

“Importantly the data showed that melatonin improved the activity of enzymatic antioxidants, including glutathione(GSH), superoxide dismutase(SOD), and malonaldehyde ( MDA ), and increased the expression levels of antioxidative genes.”