Possible Interaction: 3,4-Methylenedioxyamphetamine and Acetylcysteine

“The cell death due to combination treatment was significantly prevented by N‐Acetylcysteine and the synergistic effects were attenuated in presence of inhibitors for apoptosis and necroptosis, in MDA MB 231 and MCF 7 cells, respectively.”

“ NAC pre-treatment significantly lowered the oxidative stress brought about by pro-oxidants as seen by lowered ROS and MDA levels in the cells.”

“Our data demonstrated: …‐TOCO, and NAC , at dose used, … levels of MDA induced by DAS or NIL; 2) RES, rMnSOD, and δ‐TOCO increased the intracellular ROS levels; 3) The increase … related to higher levels of oligonucleosomesi induced by DAS and NIL and that NAC significantly reduced this activity.”

“ NAC reduced the levels of TNS, MDA , and caspase-3 expression, but increased the levels of renal tissue GSH.”

“Increased MDA level, ROS generation, nuclear condensation, shrinkage, and fragmentation in cell morphology were inhibited by NAC.”

“Of the antioxidants, only N-acetylcysteine reduced MDA levels to control values.”

“Furthermore, of the several antioxidants assessed, only N-acetylcysteine NAC ) has been shown to reduce MDA levels to control values in the Cd-treated chick embryo.”

“CK, ALT, Lactate, MDA levels were significantly higher in NAC group than control and Melatonin group (p < 0.01 for all comparisons).”

“Pretreatment with NAC showed a significant decrease in the levels of MDA , NO(x) and DNA damage.”

“ NAC pretreatment significantly reversed the elevated MDA , AChE and the reduced GSH, ChAT and ACh in the Abeta-model mice.”