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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: 2-Amino-1-Methyl-6-Phenylimidazo(4,5-B)Pyridine and Indole-3-Carbinol

Research Papers that Mention the Interaction

I3C diets also significantly decreased the concentration of urinary unmetabolized PhIP to 29.5-38.4% (0.02% I3C) and 12.8-17.8% (0.1% I3C) of values obtained with the I3C-free diet.
It is concluded that, in the female F344 rat, dietary I3C inhibits PhIP-DNA adduct formation and accelerates PhIP metabolism, probably through induction of cytochromes P450 1A1 and -1A2.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2000  |  View Paper
It is concluded that dietary I3C inhibits PhIP‐ and IQ‐DNA adduct formation in both target and nontarget organs of female rats, even with high doses of PhIP when CYP1A1 and CYP1A2, the enzymes responsible for the initial activation (N‐hydroxylation) of PhIP, are expected to be induced.
Journal of biochemical and molecular toxicology  •  1999  |  View Paper
Analysis of urine metabolites revealed that I3C and CHL decreased the excretion of unmetabolized PhIP and 4'-hydroxy- << PhIP but increased the phase II detoxification products PhIP-4'-O-glucuronide and PhIP-4'- sulfate.
Carcinogenesis  •  1995  |  View Paper