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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeic Acid
Research Papers that Mention the Interaction
“The efflux ratio of PhIP with 10 µM caffeic acid was significantly increased compared with control.”
Caffeic acid inhibits the uptake of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by inducing the efflux transporters expression in Caco-2 cells.“Among the 14 kinds of antioxidants tested, green tea catechins and the major component [(-)-epigallocatechin gallate], two flavonoids (luteolin and quercetin) and caffeic acid were found to clearly suppress the formation of both MeIQx and PhIP , being 3.2-75% of the level of the controls.”
Inhibitory effects of antioxidants on formation of heterocyclic amines.“The inhibitory effect of caffeic acid on the formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine ( PhIP ) was investigated in chemical model systems under microwave heating (MW).”
“The results showed that both for conductive heating (CV) and MW, the inhibition of PhIP increased with the concentration of caffeic acid but decreased with the prolongation of heating time.”
Caffeic acid assists microwave heating to inhibit the formation of mutagenic and carcinogenic PhIP.
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