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Last Updated: 3 years ago

Possible Interaction: Antioxidants and Methotrexate

supplement:

Antioxidants

Research Papers that Mention the Interaction

MTX use has been linked to oxidative imbalance, which may cause multi-organ toxicities that can be attenuated by antioxidant supplementation.
PloS one  •  2014  |  View Paper
Oncologists at an influential oncology institution contended that antioxidants interfere with radiation and some chemotherapies because those modalities kill by generating free radicals that are neutralized by antioxidants, and that folic acid interferes with methotrexate.
Alternative therapies in health and medicine  •  2007  |  View Paper
Oncologists at an influential oncology institution contended that antioxidants interfere with radiation and some chemotherapies because those modalities kill by generating free radicals that are neutralized by antioxidants, and that folic acid interferes with methotrexate.
Alternative therapies in health and medicine  •  2007  |  View Paper
The net results appear to show that the biological situation resulting from treatment with MTX leads to a reduction of effectiveness of the antioxidant enzyme defence system.
Cell biochemistry and function  •  1998  |  View Paper
Moreover, an association of MTX with mesna, an anti-oxidant drug , allowed to suppress the excess of hydrogen peroxide production.
Die Pharmazie  •  1994  |  View Paper
co ioxidant gene Nr f2, GCLC, HO-1, and NQO1, increasing the antioxidant enzymes superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT), reducing the oxidant substance malondialdehyde (MDA), reducing … pro-inflammatory cytokines TNFα, IL-6, IL-1β and reducing C-reactive protein (CRP), as well as alleviating the external symptoms of arthritis.
Life sciences  •  2020  |  View Paper
Taken together, antioxidants such as APC when combined with MTX not only potentiated the antiarthritic effect but importantly alleviated the MTX-induced hepatic damage, thus endorsing its effectiveness in preventing progression of articular diseases such as rheumatoid arthritis.
Free radical research  •  2018  |  View Paper
Mtx administration caused a significant decrease in TAS , a significant increase in TOS and OSI, a significant increase in MDA levels and a decrease in GSH-Px and CAT activity.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology  •  2017  |  View Paper
MTX … antioxidants in liver tissues [control group: 3.02 (2.85-3.43) μmol/g and 71.78 (61.88-97.81) U/g vs model ….62) μmol/g and 69.22 (61.13-100.88) U/g, P < 0.05 and P < 0.01 vs model group respectively].
World journal of gastroenterology  •  2014  |  View Paper
Use of these antioxidants , in combination with chemotherapeutics, may help to reduce some adverse effects of methotrexate.
Clinical and investigative medicine. Medecine clinique et experimentale  •  2014  |  View Paper
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