Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Acetylglucosamine and Glucosamine

supplement:

Glucosamine

Research Papers that Mention the Interaction

Increasing O‐GlcNAc levels, using glucosamine or PUGNAc, enhanced ubiquitination.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology  •  2008  |  View Paper
Substrate and inhibitor studies further revealed that leukaemic cell hexosaminidases hydrolyse galactopyranosides at significantly lower rates than glucopyranosides and that the hydrolysis of N-acetyl beta-D glucosamine is inhibited by both glucosamine and galactosamine products.
Leukemia research  •  1987  |  View Paper
We used a novel and reliable CI‐AKI model consisting of 5/6 nephrectomized (NE) rats, and …, 3.5gI) injected via the tail vein after dehydration for 48 h. The results showed that augmented O‐GlcNAc … glucosamine prevented the kidneys against iohexol‐induced …, tubular damage, apoptosis and oxidative stress.
We used a novel and reliable contrast‐induced acute kidney injury (CI‐AKI) model and the results showed that augmented O‐GlcNAc signaling by glucosamine prevented the kidneys against iohexol‐induced injury by the attenuation of apoptosis and oxidative stress.
Free radical biology & medicine  •  2017  |  View Paper
After 12 weeks of feeding with 0.2% GlcN and 0.2% GlcNAc , the femoral bone mineral density in OVX mice was significantly increased compared with that in OVX mice fed the control diet.
Biological & pharmaceutical bulletin  •  2016  |  View Paper
Together these observations … that both GlcN and GlcNAc may have a potential not only to induce osteoblastic cell differentiation especially at middle-late stages, but also to suppress the osteoclastic cell differentiation, thereby possibly increasing bone matrix deposition and decreasing bone resorption, and eventually modulating bone metabolism in OA.
International journal of molecular medicine  •  2011  |  View Paper
In C2C12 myotubes, O‐GlcNAc modification of PLC‐β1 was markedly enhanced in response to treatment with glucosamine (GlcNH2), an inhibitor of O‐GlcNAase (PUGNAc) and hyperglycemia.
Journal of cellular physiology  •  2006  |  View Paper
GlcNAc analogs, namely methyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-(3) and β-…,4,6-tetra-O-acetyl-2-deoxy-D-glucopyranose (5), exhibited a concentration-dependent reduction of D-[3H]glucosamine , but not of [35S]sulfate incorporation …]leucine incorporation into total protein synthesis.
Glycoconjugate Journal  •  2005  |  View Paper
N-acetylgalactosamine and N-acetylglucosamine inhibit to the greatest extent; galactosamine, glucosamine and fucose to a lesser extent.
Intervirology  •  1978  |  View Paper
Phosphorylation of d‐glucosamine was inhibited competitively by d‐glucose, 2‐deoxy‐d‐glucose and N‐acetyl‐d‐glucosamine and uncompetitively by d‐glucose‐6‐phosphate.
Journal of neurochemistry  •  1978  |  View Paper
With an increase in glucosamine concentration in the medium, an increasingly greater proportion of the intracellular radioactivity accumulates in N -acetylglucosamine 6-phosphate, glucosamine 6-phosphate, and free glucosamine (in that order), and a progressively smaller proportion is incorporated into macromolecules.
Cancer research  •  1973  |  View Paper
Show More